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KMID : 0370220210650040246
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Yakhak Hoeji
2021 Volume.65 No. 4 p.246 ~ p.257
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Recent Advances in Liposomal Drug Product Development
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Kim Jae-Cheon
Na Dong-Hee
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Abstract
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Liposomes are spherical vesicles composed of a bilayer (uni-lamellar) and/or a concentric series of multiplebilayer (multi-lamellar) separated by aqueous compartments formed by amphipathic molecules, such as phospholipids.
Liposomes deliver drugs via encapsulation in inner aqueous or lipid compartments and have advantages such as controlof drug release and distribution, alleviation of toxicity, and drug targeting. Since the launch of the first liposomal drugDoxil®, a variety of products using a liposomal drug delivery system have been developed and commercialized. Recently,several drug candidates developed with sophisticated and diverse technologies have been undergoing clinical trials. In thisreview, the pharmaceutical characteristics of approved liposomal drugs are overviewed, and the recent advances inliposome technology through candidates in clinical trials are highlighted.
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KEYWORD
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Liposome, Doxil, Liposomal drug products, Drug delivery system, Nanomedicine
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